An RNA Editor, Adenosine Deaminase Acting on Double-Stranded RNA (ADAR1)
نویسندگان
چکیده
منابع مشابه
Adenosine Deaminase Acting on RNA (ADAR1) Suppresses the Induction
4 5 Zhiqun Li, Kristina M. Okonski, and Charles E. Samuel 6 7 8 Department of Molecular, Cellular and Developmental Biology, University of California, 9 Santa Barbara, California 93106 10 11 12 13 14 Word count for abstract: 248 Word count for text: 5099 15 16 Running Title: ADAR1-mediated suppression of IFN induction by measles virus 17
متن کاملEditing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection
Adenosine deaminases that act on dsRNA (ADARs) are enzymes that target double-stranded regions of RNA converting adenosines into inosines (A-to-I editing) thus contributing to genome complexity and fine regulation of gene expression. It has been described that a member of the ADAR family, ADAR1, can target viruses and affect their replication process. Here we report evidence showing that ADAR1 ...
متن کاملAdenosine Deaminase Acting on RNA-1 (ADAR1) Inhibits HIV-1 Replication in Human Alveolar Macrophages
While exploring the effects of aerosol IFN-γ treatment in HIV-1/tuberculosis co-infected patients, we observed A to G mutations in HIV-1 envelope sequences derived from bronchoalveolar lavage (BAL) of aerosol IFN-γ-treated patients and induction of adenosine deaminase acting on RNA 1 (ADAR1) in the BAL cells. IFN-γ induced ADAR1 expression in monocyte-derived macrophages (MDM) but not T cells. ...
متن کاملDouble-stranded RNA adenosine deaminases ADAR1 and ADAR2 have overlapping specificities.
Adenosine deaminases that act on RNA (ADARs) deaminate adenosines to produce inosines within RNAs that are largely double-stranded (ds). Like most dsRNA binding proteins, the enzymes will bind to any dsRNA without apparent sequence specificity. However, once bound, ADARs deaminate certain adenosines more efficiently than others. Most of what is known about the intrinsic deamination specificity ...
متن کاملA Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase.
Editing of RNA changes the read-out of information from DNA by altering the nucleotide sequence of a transcript. One type of RNA editing found in all metazoans uses double-stranded RNA (dsRNA) as a substrate and results in the deamination of adenosine to give inosine, which is translated as guanosine. Editing thus allows variant proteins to be produced from a single pre-mRNA. A mechanism by whi...
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ژورنال
عنوان ژورنال: Journal of Interferon & Cytokine Research
سال: 2014
ISSN: 1079-9907,1557-7465
DOI: 10.1089/jir.2014.0001